Lichen planus (Latin. They are linked to allergic reactions to drugs against hypertension, cardiac weakness, arthritis and certain anti-epileptic drugs. There is also talk of ". Women are disproportionately affected by oral lichen planus (three women affected for 2 men), but otherwise it is distributed equally among both sexes.
The appearance of lichen planus is varied (see next paragraph, ". They are often pinkish red to dark red, but may also have irregular white spots (Wickham's striae). Lesions may be generalized or confined to a small area of skin or mucosa. Muscle pain and / or humatismale may accompany flares of lichen planus. The disease can range from 12 to 18 months, sometimes more.
More common in women. Men. Women...). Risk of prolonged illness of several years.
Or 'Lichen planopilaris'. Follicles are surrounded by erythema with keratotic plug, the whole forming papules spinulosiques péripilaires. Resulting in a scar-like alopecia, irreversible, this form of lichen planus rarely reaches the scalp only. Differential Diagnosis. Differential Diagnosis.
The treatment is to protect from direct sunlight.
It follows a provision of a ring of a group of papules, or a large papule evolving an active margin (typically thin) associated with a center on the mend (typically depressed and atrophic). Occasionally one finds a wide border and a small center. This provision is generally associated with other types of distribution of lesions. In humans, the annular lesions are mainly localized on the glans and can be associated with oral lesions.
Often located on the lower limbs, the lesions are usually few. It can be a healing process annular or hypertrophic lesions.
Differential Diagnosis. The lesions take many forms. The ulcerative forms are rare but evolve chronically and are often painful and resistant to treatment. The nails can be achieved, especially the big toe. Mucosa and palmoplantar extremities are spared. Reported in India or the Middle East, it may or may not be associated with typical papules.
This is the association of lichen planus and bullous pemphigoid, with the same phenomenon of creation of auto-antibodies (or immunoglobulins), different antibodies). The lesions resemble those of bullous pemphigoid. The bubbles appear both on the injured parties as healthy skin. They predominate at the ends. The blistering rash occurs in most cases after the lichen, sometimes simultaneously, and the exceptionally above. The patient's general condition may be altered.
The histological appearance is that of a lichen planus with more detachment and dermoepidermal a bubble as in sub-epidermal bullous pemphigoid. Direct immunofluorescence shows linear deposits of C3 (which trigger an inflammatory reaction) and / or immunoglobulin G (IgG) at the dermal-epidermal junction between healthy skin and the lesion of lichen. In over half the cases, there are antibodies that destroy the basement membrane attached to the front of the skin at the site of injury. It is assumed that lesions of the basal cells created by the lichen reveal antigenic determinants or create new antigens, leading to the formation of autoantibodies and the onset of skin disease resembling bullous pemphigoid. The reaction products are immune to the lamina lucida, the same place where we find the major antigen of bullous pemphigoid.
Lichen planus may have symptoms similar to those of other conditions, eg. Their local application does not present the problems posed by corticosteroids but may irritate the skin or mucous membranes. They are not recommended for pregnant or planning to become pregnant in the near future because they can cause abnormalities in children.
Creams do not contain steroids There are creams containing immunosuppressants inhibit calcineurin, similar oral medications used to prevent rejection of transplanted organs. These creams seem effective in treating mucosal lichen planus.
Antihistamine Antihistamines act on histamine, a protein involved in inflammatory activity. In oral or topical application, an antihistamine can relieve the itching and pain associated with lichen planus.
Lichen planus may be caused by certain medications, by the existence of a hepatitis C, an allergen, or any other cause to be determined. The possible actions are then.
Narrow-spectrum light therapy. The most common therapies by light, it uses the ultraviolet B (UVB) penetrates only the top layer of skin (epidermis). There is a risk of burn style ". It is best to avoid sun exposure in the few days after taking the drug involved, to avoid sunburn. During this period we must also wear sunglasses able to repel the sun's UVA.
Pityriasis Rosea